Treat prednisone-induced headaches with standard acute headache therapies, starting with NSAIDs (ibuprofen 400-800mg or naproxen 500-1000mg) as first-line treatment, and consider adding metoclopramide 10mg if nausea is present. 1 Oral prednisone was superior to placebo in reducing the frequency of attacks and should be used to attenuate the early CH episode until long-term prevention becomes effective. Discover how prednisone can offer migraine and headache relief when other treatments fall short. Learn about its uses, effectiveness, and potential side effects. Some side effects of prednisone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Current reviewed evidence on the role of steroids in primary headache suggests that steroids have a role in status migrainosus and medication overuse headache when used in the mentioned and monitored manner. Prednisone side effects include retaining fluid, mood changes and a weak immune system. Follow a healthy lifestyle and talk to your provider about your dosage. Prednisone can trigger headaches for several reasons. Learn what causes them, how long they last, and how to safely find relief. Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. Prednisone has dual role in headaches: a cause and treatment, with insights on side effects, tapering, and management strategies. Discover the most common prednisone side effects, how long they last, and actionable ways to safely manage your daily symptoms.